Searchable abstracts of presentations at key conferences in endocrinology

ea0098c24 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

68Ga-DOTATATE/18F-FDG dual PET: Utility of the NETPET score in management of G2-3 WD NENs

Nunez Jose E. , Chan David L. , Kulanthaivelu Roshini , Murad Vanessa , Singh Simron , Metser Ur

Background: The clinical heterogeneity of G2 and G3 well-differentiated GEP-NENs make it difficult to choose an effective treatment plan, highlighting the need of molecular imaging in the treatment of NETs patients. It has been suggested that a dual-tracer 68Ga-DOTATATE/18F-FDG grading scoring system could be a useful imaging biomarker. This pilot study aims to validate the prior observation from Chan et al. (BJC 2022) of variability in NETPET scores in G2-G3 WD GEP NENs and a...

ea0098b3 | Basic Science | NANETS2023

Translational biomarkers in G2-3 NENs: Analysis from NET-001 and NET-002 trials

Nunez Jose E. , Bruce Jeffrey , Danesh Arnavaz , Chan David L. , Rodriguez-Freixinos Victor , Hallet Julie , Myrehaug Sten , Law Calvin , Pugh Trevor , Singh Simron

Background: The treatment of neuroendocrine neoplasms (NENs) of higher grade remains a dilemma. In these patients the role of immunotherapy is still unclear and predictive biomarkers are an unmet need. Herein, we present a revised translational analysis of the NET001 and NET002 (NCT03278405, NCT03278379) clinical trials.Methods: Patients with advanced WHO G2-3 NENs who had a gastroenteropancreatic (GEP) or a bronchial primary (excluding typical carcinoid...